何(なに)しろNo wonder, After all, In fact, Because, At any rate

何しろ introduces a reason or emphasis, often justifying a statement, as in 何しろ忙しいので行けません (In any case, I can’t go because I’m busy). どうせ conveys resignation or futility, as in どうせ無理だ (It’s hopeless anyway). Both can be translated as ‘in any case’, but 何しろ is explanatory, while どうせ carries a negative, defeatist tone.

にしても～にしても structures a conditional to show indifference between possibilities, as in 雨にしても雪にしても中止だ (Whether rain or snow, it’s canceled). 何しろ introduces a reason or explanation, often with resignation, as in 忙しい、何しろ締め切りが近い (I’m busy; after all, the deadline is near).

Both can mean after all, but differ in nuance. 何といっても emphasizes the decisive point, as in 何といっても経験が大事だ (Above all, experience matters). 何しろ introduces a reason or background explanation, as in 忙しいんです。何しろ締め切りが近い (I’m busy, after all the deadline is near).

Both include しろ but are unrelated in usage. にせよ・にしろ means even if (A), as in 結果が悪いにせよ挑戦するべきだ (Even if the result is bad, you should try). 何しろ appears at the start of a sentence meaning anyway or after all, as in 何しろ忙しいので行けません (Anyway, I can’t go because I’m busy).

何しろ appears at the start of a sentence to give a reason, like after all, as in 何しろ忙しいので行けません (After all, I’m busy, so I can’t go). であれ follows nouns, な-adjectives, or wh-words to mean even if or no matter, often in formal contexts, as in 理由が何であれ許されない (No matter what the reason, it’s unforgivable).

何しろ introduces reasons or explanations, like after all. であれ〜であれ presents alternatives to show the result is unaffected, as in 男であれ女であれ歓迎する (Whether man or woman, they are welcome).

何しろ starts sentences with reasons, like after all. にしろ～にしろ lists two alternatives to stress the conclusion is unchanged, as in 行くにしろ行かないにしろ連絡して (Whether you go or not, let me know).

何しろ and にしても are similar in that both have a general sense of 'no matter' or 'regardless', they are used quite differently. 何しろ comes at the beginning of a sentence to express 'after all, (A)', while にしても follows a noun or phrase to specifically state 'even if (A), still (B)'.