にしては(Even) considering, (Even) for

Like として, にして highlights an aspect of something from which another thing happens. The primary difference being that と implies that (B) results from (A), while に implies that (B) happens/exists at the same time as (A). This reflects the case marking particle に's use as a location. The adverbial particle は presents the entire (A) phrase as something that will be compared.

にしては is regularly translated as 'considering (A), (B)', or 'even for (A), (B)', and may be used with both verbs and nouns. Like として, にして is often considered as a stand-alone adverbial particle, despite stemming from several parts.

Despite the 'considering (A), (B)' translation, にしては is closer in meaning to 'while (A), (B)'. This expresses that (A) and (B) share a simultaneous relation, but also that (B) is not necessarily a result of (A) at all.